The focus will be placed on the basics of protein folding/misfolding and a brief overview of techniques for studies of structural biology and biophysics of proteins involved in neurodegenerative diseases. In particular, we will mention circular dichroism, dynamic light scattering, transmission electron microscopy, and nuclear magnetic resonance. We will discuss kinetic and thermodynamics factors and intramolecular forces involved in protein folding. Example will be taken from studies of globular proteins and those involved in misfolding processes, such as amylin, amyloid-beta, and alpha-synuclein.
Contact:
Prof. Dr. Björn Corzilius (host scientist)
Institute of Chemistry
Department of Physical Chemistry
Dr.-Lorenz-Weg 2
18059 Rostock